Point mutations in POR cause severe metabolic disorder due to altered POR-CYP interactions.
POR is a central molecular hub activating a plethora of metabolic pathways by donating electrons to more than 50 different cytochrome P450 enzymes (CYPs). Interactions of Cell-Penetrating Peptide-Modified Nanoparticles with Cells Evaluated Using Single Particle Tracking. Direct Observation of Sophorolipid Micelle Docking in Model Membranes and Cells by Single Particle Studies Reveals Optimal Fusion Conditions. Ultrasmall TPGS–PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs. Ultimo June 2019 our lab will be equipped with a state of the art Olympus super resolution spinning disk microscope, thus extending the method to live 3D tracking. To do so, we deploy advanced statistical analysis in combination with machine learning - thus deciphering the mechanistic details that governs interactions at the cellular level. We aim to utilize the methodology to develop and optimize site specific and fast delivery of tailor made pharmaceuticals. By employing single particle tracking on novel nano-carriers in drug delivery, we are able to investigate their interactions with biological samples and simultaneously monitor particle mobility and drug release in live human cells.
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